Assoc. Prof. PharmDr. Jana R. Hroudová, Ph.D.
Born on 25th March 1984, Jeseník, Czech Republic
Maiden: Hroudová, Married: Rečková Hroudová
First Faculty of Medicine, Charles University, Czech Republic
· Department of Psychiatry
· Institute of Pharmacology
Tel.: +420 224 965 122, 4 135
e-mail: hroudova.jana@gmail.com, jana.hroudova@vfn.cz
orcid.org/0000-0001-5448-1717
ResearcherID: J-4067-2017
Scopus Author ID: 57055827500
psychiatrie.lf1.cuni.cz/jana-hroudova
Research focus
Preclinical studies of psychotropic drugs – effects on energy cell metabolism
Preclinical studies of newly developed drugs with cholinergic effects
Preclinical testing of drugs used as augmentation for Alzheimer's disease therapy
Clinical studies with patients from Department of Psychiatry
Laboratory domains of expertise: mitochondrial enzymes assays, high-resolution respirometry, fluorescence (ATP production, ROS production), work with cell cultures, cryosections and staining methods of CNS anatomy
Education
2018 – Associate professor in Medical pharmacology (Charles University):
Habilitation Thesis: Mitochondrial functions in neuropsychopharmacology
2016 – Attestation in Clinical pharmacy (Ministry of Health, Czech Republic)
2015 – PharmDr. Rigorosum examination: Pharmacology and Toxicology,
Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic
2008 – 2012 Ph.D. Neuroscience,
First Faculty of Medicine, Charles University, Czech Republic
Dissertation: Effects of antidepressants and depressive disorder
on mitochondrial functions
2003 – 2008 M.S. Pharmacy,
Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Czech Republic
Research experiences
2023 – 2026 Co-Investigator grant AZV No. NU23-04-00032 Mitochondrial toxicity of tau protein oligomers and its regulation by drugs for Alzheimer's disease
2017 – 2020 primary investigator - junior grant project GA ČR No. 17-07585Y: Effect of cholinesterase inhibitors on monoaminergic system and energy metabolism
2017 – 2020 Co-Investigator grant project GA ČR No. 17-05292S: Novel blood-based biomarkers for early diagnosis, prognosis and progress of Alzheimer's disease
2015 – 2018 primary investigator grant AZV No. 15-28616A: Mitochondrial dysfunctions in bipolar affective disorder
2015 – 2018 Co-Investigator grant project AZV No. 15-28967A Modulators of mitochondrial enzymes for treatment of neurodegenerative disorders
2013 - Primary Investigator, Grant FRVŠ No. 610/109/202673:
E-learning materials for course Introduction to Biological Psychiatry,
2011– 2013 Co-Investigator, Grant VZ MSM0021620849
Neuropsychiatric aspects of neurodegenerative disorders
2010 – 2012 Primary Investigator, grant GA UK No. 41310:
Effects of antidepressants and mood stabilizers on mitochondrial functions,
2009 – 2010 Co-Investigator, grant project: Effect of pharmacologically selective antidepressants on synaptic signal transduction (Zentiva, a.s. Praha),
Research fellowship
2013 – Postdoctoral Fellowship, Group of Eight, European Fellowships (6 months)
University of Melbourne, Centre for Eye Research Australia (CERA)
Research topic: Mitochondrial dysfunctions caused by mtDNA mutations
2007 – 2008 Karl - Ruprechts University, Heidelberg, Germany (Diploma thesis) (4 months)
Research awards
· Vondráček Prize 2021: Fišar Z, Ľupták M, Hroudová J: Little in vitro effect of remdesivir on mitochondrial respiration and monoamine oxidase activity in isolated mitochondria
· Awards for the best poster 2012, 2020 - conferences of Psychiatric Company ČLS JEP with international participation
· Raboch J, Hroudová J et al. Best poster award 2016, 16th International Forum on Mood and Anxiety Disorders, Rome 2016
· Participation in Lindau Nobel Laureate Meeting, 2014
· Josef Hlávka Award for the best Students and Graduates, 2013
· Prize for the best poster in category cholinergic transmission, treatment of Alzheimer’s disease, conference of Czech Neuropsychopharmacological Society, Jeseník 2013
Professional membership
· Czech Neuropharmacological Society
· Czech Psychiatric Society ČLS JEP
· Czech Society for Experimental and Clinical Pharmacology and Toxicology
· Czech Professional Society of Clinical Pharmacy
Publications
See: OBD (cuni.cz)
· Ľupták M, Fišar Z, Hroudová J. Different Effects of SSRIs, Bupropion, and Trazodone on Mitochondrial Functions and Monoamine Oxidase Isoform Activity. Antioxidants (Basel). 2023 Jun 2;12(6):1208. doi: 10.3390/antiox12061208.
· Hroudová J, Nováková T, Korábečný J, Maliňák D, Górecki L, Fišar Z. Effects of Novel Tacrine Derivatives on Mitochondrial Energy Metabolism and Monoamine Oxidase Activity-In Vitro Study. Mol Neurobiol. 2021 Mar;58(3):1102-1113. doi: 10.1007/s12035-020-02172-1.
· Singh N, Hroudová J, Fišar Z. In Vitro Effects of Cognitives and Nootropics on Mitochondrial Respiration and Monoamine Oxidase Activity. Mol Neurobiol. 2017 Oct;54(8):5894-5904. doi: 10.1007/s12035-016-0121-y.
· Hroudová J, Fišar Z, Kitzlerová E, Zvěřová M, Raboch J. Mitochondrial respiration in blood platelets of depressive patients. Mitochondrion. 2013 Nov;13(6):795-800. doi: 10.1016/j.mito.2013.05.005.
· Fišar Z, Hroudová J, Hansíková H, Spáčilová J, Lelková P, Wenchich L, Jirák R, Zvěřová M, Zeman J, Martásek P, Raboch J. Mitochondrial Respiration in the Platelets of Patients with Alzheimer's Disease. Curr Alzheimer Res. 2016;13(8):930-41. doi: 10.2174/1567205013666160314150856.